Research

Area 2

Physiopathological mechanisms of respiratory illnesses.

Team leader

Strategic objectives

1. Investigation of the molecular and cellular bases of chronic respiratory diseases, with special emphasis on pulmonary circulatory disorders and systemic
manifestations.

2. Study of the physiopathological and pathogenic mechanisms related to acute and chronic respiratory failure, focusing on chronic obstructive diseases, hepatopulmonary disorders
and obesity.

3. Evaluation of the potential of cell therapy and tissue engineering applied to respiratory diseases.

4. Development of artificial and bioartificial lung models for the support of patients with acute and chronic respiratory failure.

5. Study of the determining factors of the clinical course and healthcare resource utilization in chronic respiratory diseases.

Main lines of research


1. Biopathology and physiopathology of pulmonary circulation disorders

2. Physical activity, cell bioenergetics and systemic effects of chronic obstructive pulmonary disease (COPD)

3. Physiopathological mechanisms underlying gas exchange alterations in airway obstructive diseases

4. Interaction between systemic and pulmonary inflammation in COPD and morbid obesity

5. Tissue engineering and bioartificial lung models

6. Prognostic and determining factors of healthcare resource utilization in chronic respiratory disease

7. Analysis of inflammation and oxidative stress biomarkers in exhaled air in the study of respiratory diseases